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  • Title: Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: a single institutional experience.
    Author: Deepa R, Balapriya P, Venkatesh KG, Sabeetha T, Sasikala J, Jayalakshmi G.
    Journal: Indian J Med Microbiol; 2011; 29(4):414-7. PubMed ID: 22120805.
    Abstract:
    Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays.
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