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  • Title: Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome.
    Author: Connolly SM, Quimby SR, Griffing WL, Winkelmann RK.
    Journal: J Am Acad Dermatol; 1990 Sep; 23(3 Pt 1):451-7. PubMed ID: 2212143.
    Abstract:
    Scleroderma developed in six women who were taking L-tryptophan. Fasciitis and morphea were most common, but one patient had pleural effusion, hypertension, and signs of cardiac and kidney failure. In five patients the biopsy findings were characteristic of scleroderma; the sixth patient had Crohn's disease and developed fasciitis; her biopsy specimen showed inflammatory arteritis. All patients' conditions improved after cessation of their L-tryptophan intake, initiation of corticosteroid therapy, or both. These findings confirm previous data that show altered tryptophan-kynurenine metabolism in some patients with scleroderma and fasciitis, particularly with tryptophan loading.
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