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  • Title: The level of native and oxidized lipoprotein(a) in children with nephrotic syndrome.
    Author: Li HQ, Wu J, Niu DM, Shi YH, Zhang CN, Wang JJ.
    Journal: Clin Biochem; 2012 Jan; 45(1-2):101-5. PubMed ID: 22122998.
    Abstract:
    OBJECTIVE: To investigate lipoprotein(a) [Lp(a)], oxidized Lp(a) [ox-Lp(a)] and Lp(a) immune complex [Lp(a)-IC] levels in children with nephrotic syndrome (NS). DESIGN AND METHODS: Plasma Lp(a), ox-Lp(a) and Lp(a)-IC levels were determined in 106 NS children in acute-period, 42 in remission and 155 controls. RESULTS: Lp(a) and ox-Lp(a) levels were significantly higher in acute-period and remission NS than in control. Ox-Lp(a) levels in acute-period NS were higher than in remission. Lp(a)-IC levels in acute-period NS were higher than in control. Lp(a), ox-Lp(a) and Lp(a)-IC were found negatively related with albumin in NS. Lp(a), ox-Lp(a) and Lp(a)-IC levels decreased after use of steroid therapy. Multiple linear regression analysis found relative change of albumin, creatinine, urea, triglyceride and high density lipoprotein cholesterol accounted for 78.9% of variation in ox-Lp(a). CONCLUSIONS: Lp(a), ox-Lp(a) and Lp(a)-IC levels were increased in NS children, which may play an important role in the processes of atherosclerosis.
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