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  • Title: Quantification of amino acids in a single cell by microchip electrophoresis with chemiluminescence detection.
    Author: Liu YM, Zhao S.
    Journal: Methods Mol Biol; 2012; 828():351-8. PubMed ID: 22125158.
    Abstract:
    Analyzing individual cells allows detecting a minor group of abnormal cells present in a large population of normal cells. This ability can be essential to understanding diseases, such as cancer and diabetes. Microchip electrophoresis (MCE) is the technique of choice for single-cell analysis. However, since the channels in microfluidic devices are very small, achieving the desired assay sensitivity on a microfluidic platform remains a challenge. Here, we describe an MCE method with highly sensitive chemiluminescence detection for simultaneous determination of multiple amino acids present in single cells.
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