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  • Title: Unlocking Hydrogenation for C-C Bond Formation: A Brief Overview of Enantioselective Methods.
    Author: Hassan A, Krische MJ.
    Journal: Org Process Res Dev; 2011 Nov 18; 15(6):1236-1242. PubMed ID: 22125398.
    Abstract:
    Hydrogenation of π-unsaturated reactants in the presence of carbonyl compounds or imines promotes reductive C-C coupling, providing a byproduct-free alternative to stoichiometric organometallic reagents in an ever-increasing range of C=X (X = O, NR) additions. Under transfer hydrogenation conditions, hydrogen exchange between alcohols and π-unsaturated reactants triggers generation of electrophile-nucleophile pairs, enabling carbonyl addition directly from the alcohol oxidation level, bypassing discrete alcohol oxidation and generation of stoichiometric byproducts.
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