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  • Title: [Clinical study of preoperative radiotherapy of bladder cancer].
    Author: Shimada H, Imanaka K, Hashimura T, Hirota S, Yonezawa K, Soezima T, Izumiyama K, Kono M, Goji K, Hamami M.
    Journal: Nihon Gan Chiryo Gakkai Shi; 1990 Jul 20; 25(7):1385-90. PubMed ID: 2212829.
    Abstract:
    From May 1982 to Nov. 1987, 33 patients with bladder carcinoma were treated with preoperative radiotherapy (20 Gy/5fr) and total cystectomy. The over all 3-year survival rate was 70%. For T1 and T2, 3-year survival rate was 100%, but only 55% and 0% for T3 and T4 respectively. In 23 out of 33 patients, preoperative T-stage was confirmed by TUR-BT. Down-Staging was recognized in 7 out of 23 patients (30%). They were 0 out of 1 patients for Tcis (0%), 2 of 3 for T1 (67%), 3 of 6 for T2 (50%), 2 of 11 for T3 (18%) and 0 of 2 for T4 (0%). This protocol of preoperative radiotherapy is thought to be favorable for T1 and T2 bladder carcinoma, but inadequate for T3 and T4 tumors. Consequently, it is considered that higher dose radiotherapy and postoperative chemotherapy are necessary for T3 and T4 bladder carcinoma.
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