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  • Title: Significance of fill-in after thallium-201 reinjection following delayed imaging: comparison with regional wall motion and angiographic findings.
    Author: Tamaki N, Ohtani H, Yonekura Y, Nohara R, Kambara H, Kawai C, Hirata K, Ban T, Konishi J.
    Journal: J Nucl Med; 1990 Oct; 31(10):1617-23. PubMed ID: 2213182.
    Abstract:
    To identify reversible defects, reinjection of a small amount of thallium-201 (201Tl) following 3-hr delayed imaging was performed in 60 patients with coronary artery disease who had perfusion abnormalities on their post-exercise 201Tl images. Thallium-201 uptake was visually scored and judged as normal (Group 1), reversible defect (Group II), new fill-in after reinjection (Group IIIa) and no fill-in even after reinjection (Group IIIb). New fill-in after reinjection was observed in 27 segments of the 85 segments (32%), showing persistent defect on the stress and delayed images. The wall motion in Group IIIa was worse than Group II but better than Group IIIb. Group IIIa showed Q-wave on ECG more often (69%) than Group II (27%) (p less than 0.01), but less often than Group IIIb (85%) (p less than 0.05). These data indicate that the reinjection 201Tl imaging often identifies new fill-in in the areas of no redistribution on the delayed images and it may hold promise for assessing tissue viability which the conventional imaging may underestimate.
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