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  • Title: Episomal viral DNA in herpesvirus saimiri-transformed lymphoid cell lines.
    Author: Werner FJ, Bornkamm GW, Fleckenstein B, Mulder C.
    Journal: IARC Sci Publ (1971); 1978; (24 Pt 1):125-30. PubMed ID: 221324.
    Abstract:
    Structural analysis of episomal viral genomes from two herpesvirus saimiri (HVS)-transformed tumour cell lines (No. 1670 and 70N2) showed that both types of episomes have a higher molecular weight than linear virion DNA. The arrangement of unique (L) and repetitive (H) DNA in No. 1670 episomes was studied by partial denaturation mapping. Part of the L-sequences present in linear virion DNA was found to be missing, part was found to be duplicated in the episomes. The episomal L-DNA regions were correlated with the known physical gene maps of linear HVS DNA.
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