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  • Title: Assessment of infection with polyomaviruses BKV, JCV and SV40 in different groups of Cuban individuals.
    Author: Martínez PA, Kourí V, Cordero G, Correa C, Soto Y, Capó V, González L, Grá B, Petirena G, Silvério C, Hondal N, González M, Alvarez I, Dorticós E, Arencibia A, Jaime JC, Florin J, Pérez L, Duran DP, Marchena JJ, Solar L, Cazorla N, Pérez Y, Alemán Y, Pérez L, Álvarez A.
    Journal: Arch Virol; 2012 Feb; 157(2):315-21. PubMed ID: 22134526.
    Abstract:
    We investigated the frequency of BKV, JCV and SV40 reactivation in three groups of Cuban patients by multiplex nested PCR assay of 40 paraffin-embedded colorectal neoplasm tissues, 113 urine samples, and 125 plasma samples from 27 transplant recipients, and cerebrospinal fluid (CSF) from 67 HIV-1-infected individuals with central nervous system (CNS) disorders. None of these polyomaviruses were detected in colorectal neoplasms. JCV DNA was detected in 2 of 67 patients (2.9%) with CNS disorders, but neither BKV nor SV40 was identified. BKV was found in urine from 38.5% and 28.6% of adult and pediatric transplant recipients, respectively. In adult renal transplant recipients, excretion of BKV in urine was significantly associated with episodes of acute rejection (p=0.012) and with excretion of HCMV in urine (p= 0.008). In Cuba, the polyomaviruses studied here could not be related to colorectal neoplasms, and JCV was rarely detected in CSFs of HIV-1-infected individuals, whilst BKV reactivation was found to occur frequently in organ transplant recipients.
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