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  • Title: Estriol administration modulates luteinizing hormone secretion in women with functional hypothalamic amenorrhea.
    Author: Genazzani AD, Meczekalski B, Podfigurna-Stopa A, Santagni S, Rattighieri E, Ricchieri F, Chierchia E, Simoncini T.
    Journal: Fertil Steril; 2012 Feb; 97(2):483-8. PubMed ID: 22137494.
    Abstract:
    OBJECTIVE: To evaluate the influence of estriol administration on the hypothalamus-pituitary function and gonadotropins secretion in patients affected by functional hypothalamic amenorrhea (FHA). DESIGN: Controlled clinical study. SETTING: Patients with FHA in a clinical research environment. PATIENT(S): Twelve hypogonadotropic patients affected by FHA. INTERVENTION(S): Pulsatility study of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and a gonadotropin-releasing hormone (GnRH) test (10 μg in bolus) at baseline condition and after 8 weeks of therapy with 2 mg/day of estriol. MAIN OUTCOME MEASURE(S): Measurements of plasma LH, FSH, estradiol (E(2)), androstenedione (A), 17α-hydroxyprogesterone (17-OHP), cortisol, androstenedione (A), testosterone (T), thyroid-stimulating hormone (TSH), free triiodothyronine (fT(3)), free thyroxine (fT(4)), and insulin, and pulse detection. RESULT(S): After treatment, the FHA patients showed a statistically significant increase of LH plasma levels (from 0.7 ± 0.1 mIU/mL to 3.5 ± 0.3 mIU/mL) and a statistically significant increase of LH pulse amplitude with no changes in LH pulse frequency. In addition, the LH response to the GnRH bolus was a statistically significant increase. CONCLUSION(S): Estriol administration induced the increase of LH plasma levels in FHA and improved GnRH-induced LH secretion. These findings suggest that estriol administration modulates the neuroendocrine control of the hypothalamus-pituitary unit and induces the recovery of LH synthesis and secretion in hypogonadotropic patients with FHA.
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