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  • Title: Dental sedation for patients with intellectual disability: a prospective study of manual control versus Bispectral Index-guided target-controlled infusion of propofol.
    Author: Sakaguchi M, Higuchi H, Maeda S, Miyawaki T.
    Journal: J Clin Anesth; 2011 Dec; 23(8):636-42. PubMed ID: 22137516.
    Abstract:
    STUDY OBJECTIVE: To investigate the use of propofol sedation using Bispectral Index (BIS)-guided target-controlled infusion (TCI) in dental patients with intellectual disability. DESIGN: Single-center, prospective, randomized clinical trial. SETTING: Academic outpatient clinic. SUBJECTS: 40 ASA physical status 1 and 2 patients with intellectual disability. INTERVENTIONS: Patients were randomized to two groups. The manual control (MC) group (n = 20) had sedation by manually controlled infusion of propofol without a BIS index monitor. The BIS-TCI group (n = 20) had sedation by BIS-guided TCI of propofol. MEASUREMENTS: The required dose of propofol, recovery time for the eyelash reflex, and spontaneous eye opening times were recorded. MAIN RESULTS: BIS-TCI significantly reduced the dose of propofol and shortened the recovery times for eyelash reflex and spontaneous eye opening. CONCLUSION: Propofol sedation using BIS-guided TCI is a useful and safe method in the management of patients with intellectual disability.
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