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  • Title: Immunoadsorbent plasma perfusion in patients with systemic lupus erythematosus.
    Author: Schneider M, Berning T, Waldendorf M, Glaser J, Gerlach U.
    Journal: J Rheumatol; 1990 Jul; 17(7):900-7. PubMed ID: 2213756.
    Abstract:
    Extracorporeal treatment of acute systemic lupus erythematous (SLE) by plasmapheresis has been reported for more than 10 years. Risks of plasmapheresis include unselective procedure, an immunoadsorbent plasma perfusion by IM-P column. Eight of 10 patients evaluated improved through 3 treatments of a 2-liter perfusion. Analysis of proteins removed during plasma perfusion showed a semiselectivity of the IM-P column for circulating immune complexes and anti-dsDNA antibodies. After perfusion of 2 liters of plasma, these substances were reduced by about 35-40%, whereas whole protein was lowered by less than 10% and immunoglobulins by about 18%. Our results in severe SLE indicate that immunoadsorption having the advantage of lowering side effects by dispensing wih foreign protein substitution.
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