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  • Title: mTOR inhibitor-associated proteinuria in kidney transplant recipients.
    Author: Diekmann F, Andrés A, Oppenheimer F.
    Journal: Transplant Rev (Orlando); 2012 Jan; 26(1):27-9. PubMed ID: 22137729.
    Abstract:
    The use of mammalian target of rapamycin inhibitor (mTOR-I) after kidney transplantation has been associated with a higher incidence of proteinuria compared with calcineurin inhibitors (CNIs). This review will focus on mTOR-I-associated proteinuria in different settings after kidney transplantation: de novo mTOR-I treatment in combination with CNI, de novo mTOR-I-containing and CNI-free treatment, early conversion from a CNI-based regimen to an mTOR-I-based regimen, and late conversion. Some possible mechanisms of mTOR-I-induced proteinuria will also be reviewed.
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