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  • Title: Differences in susceptibility to herpes simplex virus infection of inbred strains of mice.
    Author: Kirchner H, Kochen M, Munk K, Hirt HM, Mergenhagen SE, Rosenstreich DL.
    Journal: IARC Sci Publ (1971); 1978; (24 Pt 2):783-8. PubMed ID: 221403.
    Abstract:
    Marked differences were observed between the susceptibility of adult C57BL/6 and DBA/2 mice to infection with HSV-1. These differences were seen after various infection schedules but were most marked after i.p. infection. A significant difference between the LD50 after i.p. infection was also observed between LPS-resistant C3H/HeJ and the closely related LPS-sensitive C3HeB/FeJ mice. Injection of LPS significantly increased the LD50 after i.p. infection with HSV in C57BL/6 or C3H/HeJ mice but not in C3HeB/FeJ mice. In vitro pretreatment with LPS was necessary to demonstrate replication of HSV in mouse spleen-cell cultures. Such replication could be demonstrated in cultures of DBA/2 and C3HeB/FeJ but not in C57BL/6 or C3H/HeJ mice.
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