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  • Title: The relationship of active ghrelin levels and intrauterine growth in preterm infants.
    Author: Sahin H, Erener T, Erginoz E, Vural M, Ilikkan B, Kavuncuoglu S, Yildiz H, Perk Y.
    Journal: Eur J Endocrinol; 2012 Mar; 166(3):399-405. PubMed ID: 22143318.
    Abstract:
    OBJECTIVE: We examined the association of active ghrelin levels with birth weight, sex, and gestational age (GA) in small for GA (SGA) and appropriate for GA (AGA) preterm infants. METHODS: Active ghrelin levels were measured by ELISA method during the first five postnatal days in 38 preterm SGA infants and 32 preterm AGA controls. RESULTS: Active ghrelin levels were significantly higher in preterm SGA infants than in preterm AGA controls (P < 0.01). Active ghrelin levels in preterms with birth weight <1500 g were statistically higher than those over 1500 g. Active ghrelin levels in preterms ≤ 34 gestational weeks were similar to those over 34 weeks. A negative correlation was detected between active ghrelin levels and birth weight (r = -0.561, P < 0.0001) as well as GA (r = -0.449, P < 0.0001). CONCLUSION: We found significantly higher active ghrelin levels in SGA preterms than those in AGA preterms and demonstrated a negative correlation between active ghrelin levels and birth weight in preterm infants. This was the first study showing a negative correlation between active ghrelin levels and birth weight in preterm infants.
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