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Title: Inhibitory modulation of the reflex tracheal constriction induced by afferent vagal stimulation. Author: Misawa M, Takahashi Y, Kamei J, Hosokawa T, Yanaura S. Journal: Jpn J Pharmacol; 1990 Aug; 53(4):506-9. PubMed ID: 2214373. Abstract: Afferent cervical vagal electrical stimulation caused a reflex tracheal constriction. Atropine changed the tracheal constriction into a tracheal dilatation that was almost inhibited by propranolol. In the hypertonic trachea with 5-hydroxytryptamine, a reflex dilatation following a constriction was observed by afferent vagal stimulation. The reflex dilatation was inhibited about 50% by propranolol and was abolished by hexamethonium. These results suggest that the adrenergic and nonadrenergic inhibitory innervations may mediate the reflex tracheal dilatation, especially in a hypertonic tracheal condition.[Abstract] [Full Text] [Related] [New Search]