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  • Title: Synthesis and antibacterial activity of novel 4-chloro-2-mercaptobenzenesulfonamide derivatives.
    Author: Sławiński J, Żołnowska B, Pirska D, Kędzia A, Kwapisz E.
    Journal: J Enzyme Inhib Med Chem; 2013 Feb; 28(1):41-51. PubMed ID: 22145585.
    Abstract:
    Few series of novel 4-chloro-2-mercaptobenzenesulfonamides have been synthesized by the reactions of N-(benzenesulfonyl)cyanamide potassium salts 7-15 with corresponding hydrazinecarbodithioic acid esters, 1-substituted carbothioic acid hydrazides, methyl 3-aminothiophene-2-carboxylate, methyl 2-aminobenzoate, 2-aminophenol or 2-aminothiophenol. The synthesized compounds (16-49) were screened in vitro for their antibacterial activity. Some of the tested compounds 16, 17, 23, 24, 31, 32 and 48 showed the promising activity against many of anaerobic Gram-positive bacteria strains.
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