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  • Title: Protein recognition by a self-assembled deep cavitand monolayer on a gold substrate.
    Author: Liu Y, Taira T, Young MC, Ajami D, Rebek J, Cheng Q, Hooley RJ.
    Journal: Langmuir; 2012 Jan 17; 28(2):1391-8. PubMed ID: 22149108.
    Abstract:
    This paper details the first use of a self-folding deep cavitand on a gold surface. A sulfide-footed deep, self-folding cavitand has been synthesized, and its attachment to a cleaned gold surface studied by electrochemical and SPR methods. Complete monolayer formation is possible if the cavitand folding is templated by noncovalent binding of choline or by addition of space-filling thiols to cover any gaps in the cavitand adsorption layer. The cavitand is capable of binding trimethylammonium-tagged guests from an aqueous medium and can be deposited in 2 × 2 microarrays on the surface for characterization by SPR imaging techniques. When biotin-labeled guests are used, the cavitand:guest construct can recognize and immobilize streptavidin proteins from aqueous solution, acting as an effective supramolecular biosensor for monitoring protein recognition.
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