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  • Title: Integrity of the cytoskeletal system is important for phagocytosis by Kupffer cells.
    Author: Watanabe S, Hirose M, Ueno T, Kominami E, Namihisa T.
    Journal: Liver; 1990 Aug; 10(4):249-54. PubMed ID: 2215096.
    Abstract:
    The mechanism of phagocytosis by Kupffer cells is believed to involve the Ca2(+)-calmodulin system. However, the role of myosin in this system is still unknown. In this study, we found that myosin light chain kinase inhibitor (ML-9) inhibited phagocytosis by cultured Kupffer cells using polystyrene beads, a time-lapse VTR system and fluorescent staining techniques. The inhibitory effects of ML-9 suggest that myosin may be involved in this complex cellular function and that the integrity of the cytoskeletal system is essential for normal phagocytosis.
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