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  • Title: Richter syndrome and brain involvement: low-grade lymphoma relapsing as cerebral high-grade lymphoma.
    Author: Stuplich M, Mayer K, Kim Y, Thanendrarajan S, Simon M, Schäfer N, Glas M, Schmidt-Wolf IG, Herrlinger U.
    Journal: Acta Haematol; 2012; 127(2):93-5. PubMed ID: 22156510.
    Abstract:
    Richter syndrome (RS) describes the development of high-grade non-Hodgkin's lymphoma (NHL) from low-grade NHL. RS isolated to the brain is very rare and has a poor prognosis. We describe the cases of high-grade large B-cell diffuse NHL in a 56-year-old male with chronic lymphocytic leukemia and in a 71-year-old female with previously unknown low-grade NHL, both with initial appearance of neurological symptoms. This report extends the literature of central nervous system RS and particularly highlights the importance of a thorough diagnostic evaluation of patients with low-grade NHL presenting with neurological symptoms.
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