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  • Title: Association of polymorphisms in the AGT gene with essential hypertension in the Chinese population.
    Author: Xi B, Shen Y, Yan Y, Mi J.
    Journal: J Renin Angiotensin Aldosterone Syst; 2012 Jun; 13(2):282-8. PubMed ID: 22156763.
    Abstract:
    OBJECTIVE: Although the angiotensinogen (AGT) gene has been implicated in the pathogenesis of essential hypertension, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of A-6G, A-20C and G-217A polymorphisms in the AGT gene with essential hypertension in the Chinese population. METHODS: Published literature from PubMed, Embase, China National Knowledge Infrastructure, China Biological Medicine and Wanfang Data was retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models. RESULTS: Sixteen studies (4223 cases and 3743 controls) for A-6G polymorphism, ten studies (3116 cases and 2678 controls) for A-20C polymorphism and five studies (1268 cases and 1081 controls) for G-217A polymorphism were identified. The results from the meta-analyses indicated significant association of all three polymorphism with the risk of essential hypertension in the Chinese population (A-6G polymorphism: GG vs AA: OR = 1.45, 95% CI 1.17-1.81; A-20C polymorphism: CC vs AA: OR = 1.52, 95% CI 1.10-2.08; G-217A polymorphism: AA vs GG: OR = 2.36, 95% CI 1.44-3.89). CONCLUSIONS: Our study indicated that three polymorphisms (A-6G, A-20C and G-217A) in the AGT gene are associated with essential hypertension in the Chinese population.
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