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  • Title: Two types of thyrotropes (TSH cells) in the adenohypophysis of the untreated mouse.
    Author: Iwama Y, Hasegawa K.
    Journal: Okajimas Folia Anat Jpn; 1990 Aug; 67(2-3):175-81. PubMed ID: 2216311.
    Abstract:
    Employing immunohistochemical techniques with OsO4 single fixation, we identified mouse pituitary thyrotropes (TSH cells). The cells stained with TSH antiserum are angular or slender with a small nucleus. These cells contain small secretory granules (about 120-200 nm in diameter) and numbers of cored vesicles, either attached to the cell membranes or lying free in a relatively electron transparent cytoplasm. In the untreated male mouse, the TSH cell modifies its morphology according to the functional phase. The first form of TSH cells [Type I] is small. The endoplasmic reticulum and the Golgi apparatus are not prominent, and secretory granules are very few. In the second hypertrophied form [Type II], the endoplasmic reticulum is very prominent and occurs as a series of grossly dilated sacs of irregular shape. The Golgi apparatus is greatly enlarged and a large number of electron-dense secretory granules and cored vesicles are observed. Type II thyrotropes are rarely encountered in normal tissue.
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