These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Dynamic changes of early immune responses to attenuated Schistosoma japonicum cercariae induced in BALB/c mice].
    Author: Zhou X, Qiu YH, Gong W, Liu CC, Zhang J, Luo W, Zhu-Ge HX.
    Journal: Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi; 2011 Aug; 23(4):419-23. PubMed ID: 22164856.
    Abstract:
    OBJECTIVE: To study the early immune activation and its dynamic changes between the attenuated cercariae immunized mice and the normal infected mice. METHODS: The dendritic cell surface molecules CD11c and T cell surface molecule CD25 expression differences and CD3+CD25+/CD3+ T ratio of the early spleen and/or lung of the attenuated cercariae immunized mice and normal mice were assayed and compared by FCM and IHC, and the immune activation and dynamics of T cells were analyzed. RESULTS: CD3+CD25+CD3+ T ratio in the spleen cells 7 days post-infection in the immunized group and the normal infected group were (19.52 +/- 3.65)% and (22.12 +/- 3.24)%, respectively; the rates of 14 days and 21 days post-infection were (28.73 +/- 3.94)%, (13.68 +/- 3.64)% and(26.43 +/- 0.40)%, (14.42 +/- 2.24)%, respectively. The expressions of CD11c+DC in the lung of the two groups were (1.05 +/- 0.16)%, (0.96 +/- 0.15)%, (1.34 +/- 0.15)%, (1.09 +/- 0.17)%, (1.49 +/- 0.14)%, (0.97 +/- 0.16)%, respectively; the expressions in the spleen were (2.05 +/- 0.26)%, (1.95 +/- 0.18)%, (2.24 +/- 0.25)%, (2.17 +/- 0.25)%, and (2.18 +/- 0.26)%, (2.06 +/- 0.18)%, respectively, on the 7, 14 and 21 days post-infection. The expressions of CD25+T cells in the lung of the two groups were (1.24 +/- 0.13)%, (1.17 +/- 0.16)%, (1.48 +/- 0.11)%, (1.25 +/- 0.13)%, and (1.55 +/- 0.14)%, (0.97 +/- 0.12)%, respectively; the expressions in the spleen were (3.25 +/- 0.22)%, (2.93 +/- 0.20)%, (4.57 +/- 0.23)%, (3.69 +/- 0.24)% and (4.28 +/- 0.24)%, (3.86 +/- 0.26)%, respectively, on the 7, 14 and 21 days post-infection. The CD3+CD25+/CD3+T rate in the infection control group was significantly higher than that in the cercariae attenuated group, while 14, 21 days post-infection the rates of the attenuated group were significantly higher than those in the normal control group. On the 7, 14 and 21 days post-infection, the lung tissue of the attenuated cercariae immunized mice raised more CD11c+ DC and CD25+ T cells than that of the normal infected mice did. CONCLUSIONS: The activation of T cells of the immune group and the activation of pulmonary dendritic cells are higher than those in the control group 7 and 14 days post-infection, suggesting that attenuated cercariae in the lungs can raise more antigen presenting cells and their activation.
    [Abstract] [Full Text] [Related] [New Search]