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  • Title: [Changes of alveolar macrophage phagocytosis and TNF-alpha, IL-6 of rats with Pneumocystis pneumonia].
    Author: Lu ZM, Wang Y, Zhang XC, Tang HW.
    Journal: Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi; 2011 Aug; 23(4):428-30. PubMed ID: 22164858.
    Abstract:
    OBJECTIVE: To observe the changes of alveolar macrophage (AM) phagocytosis and the levels of TNF-alpha and IL-6 in AM supernatants and bronchoalveolar lavage fluid (BALF) of rats with Pneumocystis pneumonia (PCP). METHODS: Wistar rats were injected with dexamethasone intramuscularly and continually to establish the model of PCP, the AM phagocytosis and levels of TNF-alpha and IL-6 in AM supernatants and BALF of rats with PCP were detected, meanwhile, the normal controls were set. RESULTS: The phagocyting percentage [(20.61 +/- 2.04)%] and phagocyting index (0.25 +/- 0.21) of the PCP group were significantly lower than those [(25.45 +/- 3.1)% and (0.31 +/- 0.16)] of the control group (P < 0.05), TNF-alpha (16.84 +/- 0.86) pg/ml and IL-6 (1.05 +/- 0.19) pg/ml in BALF of the PCP group were significantly higher than those [(12.48 +/- 0.84) pg/ml and (0.86 +/- 0.11) pg/ml] of the control group (P < 0.05), but there were no significant differences for the levels of TNF-alpha and IL-6 in AM supernatants between the two groups (P > 0.05). CONCLUSION: AM phagocytosis reduces evidently of PCP rats, but the levels of TNF-alpha and IL-6 in BALF rise evidently.
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