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  • Title: [The dehydroepiandrosterone sulfate influence on anxiety and depressive behaviour: participation of mu-opioid receptors].
    Author: Ovsiukova MV, Obut TA, Saryg SK.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2011 Sep; 97(9):903-13. PubMed ID: 22165202.
    Abstract:
    The dehydroepiandrosterone sulfate (DHEAS) influence on anxiety and depressive behaviour was studied in animals after chronic stress exposures. It is shown that DHEAS (30 mg/kg) reduced anxiety in submission (with increased level of stress-induced anxiety resulting from chronic (20-days) defeats in aggressive interactions) of male mice of CBA/Lac strain in the "partition" test and in the plus-maze test, whereas in the control--only in the plus-maze test. DHEAS injection (30 mg/kg) in male Wistar rats decreased depressive behaviour in the Porsolt test in control and multiple (shuttling on the laboratory scrambler for 18 days by 1 hour in day) stressed animals. NaItrexone (0.25 mg/kg in mice and 0.1 mg/kg in rats) blocked anxiolytic and antidepressant-like effects of DHEAS. The findings suggest that these DHEAS effects are mediated by mu-opioid receptors.
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