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  • Title: Acquired von Willebrand's disease and hypothyroidism: report of a case presenting with menorrhagia.
    Author: Blesing NE, Hambley H, McDonald GA.
    Journal: Postgrad Med J; 1990 Jun; 66(776):474-6. PubMed ID: 2217000.
    Abstract:
    A 17 year old woman presented with severe anaemia due to menorrhagia. On investigation, she was shown to have abnormalities of her haemostatic mechanism consistent with von Willebrand's disease Type I, although there was no family history of this disorder. In addition, she was shown to have severe primary hypothyroidism. On correction of hypothyroidism with oral thyroxine, her coagulation defects returned to normal and menorrhagia ceased. This is consistent with acquired von Willebrand's disease secondary to hypothyroidism.
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