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  • Title: Molecular physiology of pH-sensitive background K(2P) channels.
    Author: Lesage F, Barhanin J.
    Journal: Physiology (Bethesda); 2011 Dec; 26(6):424-37. PubMed ID: 22170960.
    Abstract:
    Background K(2P) channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K(2P) channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K(2P) channels.
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