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  • Title: [A case of lung injury induced by long-term administration of mesalazine].
    Author: Shindoh Y, Horaguchi R, Hayashi K, Suda Y, Iijima H, Shindoh C.
    Journal: Nihon Kokyuki Gakkai Zasshi; 2011 Nov; 49(11):861-6. PubMed ID: 22171492.
    Abstract:
    A 52-year-old man was given a diagnosis of ulcerative colitis and treated with mesalazine for 7.5 years. However, the unusually long administration of mesalazine induced lung injury and the patient complained of a dry cough and dyspnea on limited exertion. Infiltrative shadows were observed in bilateral lung fields on a chest radiograph and computed tomographic images. The histological findings obtained by transbronchial biopsy and bronchoalveolar lavage showed organizing pneumonia. His drug-induced lymphocyte stimulation test (DLST) for mesalazine was positive. Improvements in his clinical symptoms and radiographic abnormalities occurred spontaneously after the discontinuation of mesalazine. This case indicates that the long-term administration of mesalazine may lead to an adverse pulmonary reaction.
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