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  • Title: Molecular epidemiology of Rift Valley fever virus.
    Author: Grobbelaar AA, Weyer J, Leman PA, Kemp A, Paweska JT, Swanepoel R.
    Journal: Emerg Infect Dis; 2011 Dec; 17(12):2270-6. PubMed ID: 22172568.
    Abstract:
    Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.
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