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  • Title: Gold-catalyzed three-component annulation: efficient synthesis of highly functionalized dihydropyrazoles from alkynes, hydrazines, and aldehydes or ketones.
    Author: Suzuki Y, Naoe S, Oishi S, Fujii N, Ohno H.
    Journal: Org Lett; 2012 Jan 06; 14(1):326-9. PubMed ID: 22176630.
    Abstract:
    Polysubstituted dihydropyrazoles were directly obtained by a gold-catalyzed three-component annulation. This reaction consists of a Mannich-type coupling of alkynes with N,N'-disubstituted hydrazines and aldehydes/ketones followed by intramolecular hydroamination. Cascade cyclization using 1,2-dialkynylbenzene derivatives as the alkyne component was also performed producing fused tricyclic dihydropyrazoles in good yields.
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