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  • Title: The methylthiolation reaction mediated by the Radical-SAM enzymes.
    Author: Atta M, Arragain S, Fontecave M, Mulliez E, Hunt JF, Luff JD, Forouhar F.
    Journal: Biochim Biophys Acta; 2012 Nov; 1824(11):1223-30. PubMed ID: 22178611.
    Abstract:
    Over the past 10 years, considerable progress has been made in our understanding of the mechanistic enzymology of the Radical-SAM enzymes. It is now clear that these enzymes appear to be involved in a remarkably wide range of chemically challenging reactions. This review article highlights mechanistic and structural aspects of the methylthiotransferases (MTTases) sub-class of the Radical-SAM enzymes. The mechanism of methylthio insertion, now observed to be performed by three different enzymes is an exciting unsolved problem. This article is part of a Special Issue entitled: Radical SAM enzymes and Radical Enzymology.
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