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  • Title: Synthesis and antitumor activity of dehydroepiandrosterone derivatives on Es-2, A549, and HepG2 cells in vitro.
    Author: Liu XK, Ye BJ, Wu Y, Nan JX, Lin ZH, Piao HR.
    Journal: Chem Biol Drug Des; 2012 Apr; 79(4):523-9. PubMed ID: 22181987.
    Abstract:
    A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES-2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c, 2i, and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES-2 cells, A549 cells, and HepG2 cells, respectively.
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