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  • Title: A malignant case of acute promyelocytic leukemia with occlusion of carotid artery by tumor thrombus.
    Author: Nicholas-Bublick S, Irlam JH, Tietjen G.
    Journal: J Stroke Cerebrovasc Dis; 2012 May; 21(4):325-6. PubMed ID: 22182759.
    Abstract:
    We report an unusual and malignant presentation of acute promyelocytic leukemia (APL) resulting in thrombosis of a cervicocephalic artery by tumor in a healthy 37-year-old woman. The patient's rapid decline and multiorgan involvement proved to be a diagnostic and therapeutic challenge, and despite the efforts of a coordinated multidisciplinary health care team, she suffered a cardiac arrest and died within 48 hours of presentation to the emergency department. Autopsy revealed an APL-related tumor thrombus obstructing the left internal carotid artery, which to the best of our knowledge has not yet been described as a cause of fatal stroke.
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