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  • Title: Is gluten challenge necessary for the diagnosis of coeliac disease in young children?
    Author: Danielsson L, Stenhammar L, Aström E.
    Journal: Scand J Gastroenterol; 1990 Sep; 25(9):957-60. PubMed ID: 2218400.
    Abstract:
    Sixty-seven children under 2 years of age presenting with a classic clinical picture of coeliac disease with a severe small-intestinal mucosal lesion were investigated. All improved clinically and histologically on a gluten-free diet. During gluten challenge the mucosal damage recurred in 64 (95.5%) children, thus fulfilling the criteria for coeliac disease formulated by the European Society for Paediatric Gastroenterology and Nutrition. Three (4.5%) children had no mucosal relapse 2 years or more after return to a gluten-containing diet. These children were classified as having transient gluten intolerance. The low frequency of non-relapsers in the present study calls into question the practice of performing gluten challenge.
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