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  • Title: [Atherosclerotic nephropathy. Clinical manifestations of chronic arterial circulatory insufficiency of the kidneys].
    Author: Krapf R.
    Journal: Schweiz Med Wochenschr; 1990 Sep 29; 120(39):1415-20. PubMed ID: 2218463.
    Abstract:
    Atherosclerotic nephropathy is defined as renal insufficiency due to atheromatous disease of the main renal arteries and/or their branches. This disease essentially is characterized by atheromatous lesions in the renal arteries which compromise arterial renal blood flow. Clinically, patients with atherosclerotic nephropathy can present with refractory hypertension and renal insufficiency, acute renal failure after treatment with antihypertensive drugs and unexplained, slowly progressive renal failure with or without hypertension (elderly patients). Observations from uncontrolled studies indicate that both the progression of renal insufficiency and the control of hypertension can be influenced favorably in about 80% of the cases by a revascularization procedure (arterial anastomosis, percutaneous arterial dilatation). Patients with suspected atherosclerotic nephropathy should probably be evaluated invasively and considered candidates for a revascularization procedure. The benefits of these therapies compared to conservative management need, however, evaluation in a controlled, prospective clinical trial.
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