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  • Title: Total synthesis of halichondrin C.
    Author: Yamamoto A, Ueda A, Brémond P, Tiseni PS, Kishi Y.
    Journal: J Am Chem Soc; 2012 Jan 18; 134(2):893-6. PubMed ID: 22188422.
    Abstract:
    The first total synthesis of halichondrin C has been completed, highlighted by development of the synthetic method to construct the C8-C14 polycycle. Cr-mediated coupling reactions are used seven times to form a new C-C bond. The acid stability of halichondrin C is studied, demonstrating that the macrolactone stabilizes the C8-C14 polycycle, relative to the one present in the C1-C16 model.
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