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  • Title: Synthesis of novel histamine H4 receptor antagonists.
    Author: Lane CA, Hay D, Mowbray CE, Paradowski M, Selby MD, Swain NA, Williams DH.
    Journal: Bioorg Med Chem Lett; 2012 Jan 15; 22(2):1156-9. PubMed ID: 22189138.
    Abstract:
    This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.
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