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  • Title: Synthesis and antioxidant and antitumor activity of novel pyridine, chromene, thiophene and thiazole derivatives.
    Author: Fadda AA, Berghot MA, Amer FA, Badawy DS, Bayoumy NM.
    Journal: Arch Pharm (Weinheim); 2012 May; 345(5):378-85. PubMed ID: 22189501.
    Abstract:
    2-Tosylacetonitrile (1) when reacted with α,β-unsaturated nitriles 2a-c or a mixture of formaldehyde and 3-amino-2-substituted-pent-2-endinitriles 6a,b yielded pyridine derivatives 3a-c and 9a,b, respectively, while when subjected to react with salicylaldehyde yielded chromene derivatives 4 and 5, subsequently. The behavior of thiocarbamoyl derivative 10 derived from 1 towards some α-halogenated compounds have been investigated as well as its behavior towards elemental sulfur and phenyl isothiocyanate. Newly synthesized compounds were screened for their antioxidant activity, erythrocytes haemolysis and bleomycin-independent DNA damage. Some of the tested compounds exhibited promising activities.
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