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  • Title: Preparation of electrospun PLGA-silk fibroin nanofibers-based nerve conduits and evaluation in vivo.
    Author: Li S, Wu H, Hu XD, Tu CQ, Pei FX, Wang GL, Lin W, Fan HS.
    Journal: Artif Cells Blood Substit Immobil Biotechnol; 2012 Feb; 40(1-2):171-8. PubMed ID: 22192071.
    Abstract:
    With advances in technical methodology, the grafting of biocompatible conduits may become a viable alternative for the reconstruction of nerve gaps. In this study, electrospinning was used to fabricate nerve conduits (NCs) from poly(L-lactide-coglycolide)-silk fibroin. Conduits or autograft nerves were employed to bridge 10 mm defects in the sciatic nerves of Sprague-Dawley rats. Six weeks after the operation, morphological and functional assessment showed that nerve conduits from PLGA-silk fibroin grafts promoted the regeneration of peripheral nerves. The effects were similar to those obtained using nerve autografts. This method offers a promising alternative to the use of nerve autografts.
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