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  • Title: [Function and biological activities of the autotaxin-LPA axis].
    Author: Li ZW, Zhao YR, Zhao C, Fu R, Li ZY.
    Journal: Sheng Li Xue Bao; 2011 Dec 25; 63(6):601-10. PubMed ID: 22193457.
    Abstract:
    Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.
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