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  • Title: Endometrioid adenocarcinoma arising from endometriosis: a case report.
    Author: Micha JP, Mendivil AA, Epstein HD, Laflamme LA, Goldstein BH.
    Journal: J Reprod Med; 2011; 56(11-12):507-10. PubMed ID: 22195335.
    Abstract:
    BACKGROUND: Endometriosis is frequently identified in the ovaries, rectum, pelvic peritoneum, cervix and vagina. However, endometriosis undergoing malignant transformation is a rare event, particularly when the condition manifests itself promptly after initial surgical management. CASE: We present a case involving a 52-year-old woman who tested positive for the BRCA1 mutation and was diagnosed with endometriosis in 1999. Two years following treatment, the patient presented with an endometrioid adenocarcinoma; pathologic evaluation indicated that the neoplasm originated from the endometriosis. CONCLUSION: Malignant transformation is a very unusual event and reportedly occurs over several years. Nevertheless, considering the current patient's relatively sudden onset of disease, oncologists should maintain a high index of suspicion in high-risk patients treated surgically for endometriosis who re-present with pelvic symptoms.
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