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  • Title: Development of FRET-based ratiometric fluorescent Cu2+ chemodosimeters and the applications for living cell imaging.
    Author: Yuan L, Lin W, Chen B, Xie Y.
    Journal: Org Lett; 2012 Jan 20; 14(2):432-5. PubMed ID: 22201292.
    Abstract:
    Coumarin-rhodamine-based compounds 1a,b were rationally designed and synthesized as novel FRET ratiometric fluorescent chemodosimeters. Ratiometric chemodosimeters 1a,b exhibit several favorable features, including a large variation in the emission ratio, well-resolved emission peaks, high sensitivity, high selectivity, low cytotoxicity, and good cell membrane permeability. Importantly, these excellent attributes enable us to demonstrate ratiometric imaging of Cu(2+) in living cells by using these novel ratiometric fluorescent chemodosimeters.
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