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  • Title: [Treatment of S-1 plus weekly CDDP for advanced gastric cancer].
    Author: Kemmochi T, Egawa T, Mihara Y, Irino T, Ito Y, Nagashima A, Makino H, Yamamuro W.
    Journal: Gan To Kagaku Ryoho; 2011 Nov; 38(12):2351-3. PubMed ID: 22202379.
    Abstract:
    We analyzed the clinical efficacy and safety of chemotherapy using S-1 plus weekly CDDP( w-CS therapy) for unresectable gastric cancer. Twenty one patients were treated with this treatment. S-1 80 mg/m²/day was administered for 2 weeks followed by a 1-week rest. CDDP 20 mg/m² was injected intravenously on day 1 and 8. The overall response rate was 52. 3%. The disease control rate was 85.7%. Grade 3 or 4 major toxicity comprised neutropenia (14.2%), thrombocytopenia (4.7%) and plasma creatinine elevation (4.7%). w-CS therapy is satisfied resulting with efficacy and safety. Thus, future clinical trials and accumulation of futher cases are warranted.
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