These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Restoration of the gonadotrophin response to LH-RH and oestrogen administration in patients after molar abortion.
    Author: Miyake A, Aono T, Tanizawa O, Kurachi H, Kurachi K.
    Journal: Acta Endocrinol (Copenh); 1979 May; 91(1):30-5. PubMed ID: 222100.
    Abstract:
    The relation of the hypothalamic-pituitary effect on gonadotrophin secretion and the concentration of serum hCG after molar abortion was investigated. Gonadotrophin release after a bolus injection of LH-RH or conjugated oestrogens was observed in 17 women until 5 months after molar abortion. Little if any response of gonadotrophin was observed at a hCG level of 100 mIU/ml or more, but the response of LH and FSH to LH-RH were restored to normal when the serum hCG level decreased to below 100 mIU/ml. A normal response of LH to conjugated oestrogens was observed at a serum hCG level of 20 mIU/ml or less. These findings suggest that a high level of hCG interferes with pituitary gonadotrophin secretion, that the threshold hCG levels for normal responses of gonadotrophins to LH-RH and oestrogen are 100 and 20 mIU/ml, respectively, and that secretion of gonadotrophins is restored even in the presence of a low hCG level. The effect of serum human chorionic gonadotropin (hCG) level on gonadotropin response to a single intravenous injection of luteinizing hormone-releasing hormone (LH-RH) or conjugated estrogen (Premarin) was investigated in patients after abortion of a hydatidiform mole. 17 women (aged 23-29 years) with an aborted mole without theca lutein cyst were examined until 5 months after molar abortion. Response to gonadotropin was little at a hCG level of 100 mIU/ml or more, but the response of LH and follicle stimulating hormone (FSH) to LH-RH was restored to normal when the serum hCG level decreased to below 100 mIU/ml. A normal response of LH to conjugated estrogens was observed at a serum hCG level of 20 mIU/ml or less. Apparently, a high level of hCG interferes with pituitary gonadotropin secretion. The threshold hCG levels for normal responses of gonadotropins to LH-RH and estrogens are 100 and 20 mIU/ml, respectively. The secretion of gonadotropins was restored even in the presence of low hCG with either LH-RH or conjugated estrogen induction.
    [Abstract] [Full Text] [Related] [New Search]