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  • Title: Value of the DST for predicting response of patients with major depression to hospitalization and desipramine.
    Author: Nelson JC, Mazure CM, Jatlow PI.
    Journal: Am J Psychiatry; 1990 Nov; 147(11):1488-92. PubMed ID: 2221161.
    Abstract:
    The authors examined the value of the dexamethasone suppression test (DST) for predicting response of patients with unipolar, nonpsychotic major depression to 1 week of hospitalization without antidepressant drugs and to a 4-week trial of desipramine at a fixed plasma level. The rates of response to hospitalization without drug treatment (defined as a score of 12 or less on the Hamilton Rating Scale for Depression) were not significantly different for the patients with a positive DST and those with a negative DST. This finding differs from those of prior studies of the DST and response to placebo. The responses of the DST-positive and DST-negative patients to desipramine also did not differ, a finding that replicates those in some prior reports.
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