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  • Title: Connectable DNA logic gates: OR and XOR logics.
    Author: Gerasimova YV, Kolpashchikov DM.
    Journal: Chem Asian J; 2012 Mar 05; 7(3):534-40. PubMed ID: 22213731.
    Abstract:
    Modern computer processors are based on semiconductor logic gates connected to each other in complex circuits. This study contributes to the development of a new class of connectable logic gates made of DNA in which the transfer of oligonucleotide fragments as input/output signals occurs upon hybridization of DNA sequences. The DNA strands responsible for a logic function form associates containing immobile DNA four-way junction structures when the signal is high and dissociate into separate strands when the signal is low. A basic set of logic gates (NOT, AND, and OR) was designed. Two NOT gates, two AND gates, and an OR gate were connected in a network that corresponds to an XOR logic function. The design of the logic gates presented here may contribute to the development of the first biocompatible molecular computer.
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