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  • Title: Alpha-adrenoceptor blocking drugs in asthma.
    Author: Patel KR.
    Journal: Br J Clin Pharmacol; 1976 Aug; 3(4):601-5. PubMed ID: 22216501.
    Abstract:
    The effect of alpha-adrenoceptor blocking drug, thymoxamine alone and in combination with isoprenaline, was studied on the specific airways conductance (SGaw) in ten patients with extrinsic asthma. Thymoxamine when given together with isoprenaline produced significantly greater increase in SGaw as compared to improvement achieved with isoprenaline alone. It is suggested that the potentiation of isoprenaline induced bronchodilatation by thymoxamine is mediated by increased cyclic AMP formation in the bronchial smooth muscle.
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