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  • Title: Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature.
    Author: Kamenetsky Z, Da'as N, Esayag Y, Kleinman Y, Samuels N.
    Journal: Neurologist; 2012 Jan; 18(1):39-40. PubMed ID: 22217614.
    Abstract:
    We present a case of eosinophilic pleural effusion due to valproic acid (VPA), a rare adverse event that has been reported previously. A 30-year-old male patient presented with respiratory symptoms and right-sided pleuritic pain, within days of initiation of VPA treatment for a generalized seizure. Chest radiography revealed a moderate-sized right-sided pleural effusion, which was an exudate with a pH of 7.54 and 48% eosinophils. Symptoms resolved soon after discontinuation of the drug, as did the effusion in a repeat radiograph 3 weeks later. The likelihood that VPA was the cause of the effusion is examined.
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