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  • Title: Aggressive multifocal form of epithelioid hemangioendothelioma--case report.
    Author: Duletić-Nacinović A, Grohovac D, Dobrila-Dintinjana R, Brncić N, Jonjić N.
    Journal: Coll Antropol; 2011 Sep; 35 Suppl 2():289-93. PubMed ID: 22220455.
    Abstract:
    Epithelioid hemangioendothelioma (EHE) is a rare tumor of the vascular origin. It was first described in its pulmonary form by Dail and Leibow in 1975 and named "intravascular bronchioalveolar tumor" (IVBAT). Since then, reports of occurrences of the tumor have been made for number of locations, but most often tumor can be found in soft tissues, liver, lungs, bone and skin. It is considered to be a low or borderline malignant tumor with, usually, slow progression, but aggressive forms have been described. We here report a case of a 46-year old female patient with multifocal malignant tumor spreading to lungs, liver, spleen and with synchronous involvement of lumbal vertebrae, illiac bones and central nervous system dissemination. To the best of the authors knowledge, no case of malignant EHE with multiorgan involvement of this proportions and synchronous central nervous system and bone involvement in one patient has been reported to this date in English-speaking literature.
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