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  • Title: Synthesis and characterization of core-shell Fe₃O₄-gold-chitosan nanostructure.
    Author: Salehizadeh H, Hekmatian E, Sadeghi M, Kennedy K.
    Journal: J Nanobiotechnology; 2012 Jan 05; 10():3. PubMed ID: 22221555.
    Abstract:
    BACKGROUND: Fe₃O₄-gold-chitosan core-shell nanostructure can be used in biotechnological and biomedical applications such as magnetic bioseparation, water and wastewater treatment, biodetection and bioimaging, drug delivery, and cancer treatment. RESULTS: Magnetite nanoparticles with an average size of 9.8 nm in diameter were synthesized using the chemical co-precipitation method. A gold-coated Fe₃O₄ monotonous core-shell nanostructure was produced with an average size of 15 nm in diameter by glucose reduction of Au³⁺ which is then stabilized with a chitosan cross linked by formaldehyde. The results of analyses with X-ray diffraction (XRD), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Atomic Force Microscopy (AFM) indicated that the nanoparticles were regularly shaped, and agglomerate-free, with a narrow size distribution. CONCLUSIONS: A rapid, mild method for synthesizing Fe₃O₄-gold nanoparticles using chitosan was investigated. A magnetic core-shell-chitosan nanocomposite, including both the supermagnetic properties of iron oxide and the optical characteristics of colloidal gold nanoparticles, was synthesized.
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